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The theoretical concern is real

To investigate the targeting mechanism of cPLT, inflamed cells were pre-incubated with an excess of free anti-vWF antibody for 30 min to block the vWF binding sites, followed by the addition of DiO-labeled cPLT as described above

2017;6(6):CD003726

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Briefly, ion transfer tube temp = 300 C, Easy-IC internal mass calibration, default charge state = 2, and cycle time = 3 s